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Title : Reirradiation + ketogenic diet + intermittent fasting, randomized trial
link : Reirradiation + ketogenic diet + intermittent fasting, randomized trial

Reirradiation + ketogenic diet + intermittent fasting, randomized trial

ERGO2: A prospective randomized trial of calorie restricted ketogenic diet and fasting in addition to re-irradiation for malignant glioma
https://sci-hub.tw/https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf    (full PDF from sci-hub)

https://www.redjournal.org/article/S0360-3016(20)31308-0/pdf   (link to journal abstract, full PDF requires a payment)

Half the patients were randomized to re-irradiation plus standard diet (SD), the other half were randomized to re-irradiation plus ketogenic diet plus intermittent fasting (KD-IF).

• PFS6 was not significantly different between the two groups (KD-IF: 20%, SD: 16%). 
• Similarly, no difference in PFS, local PFS6 and OS was observable.
• Explorative analysis revealed that patients of the KD-IF group who had a glucose of less than the median (83.5 mg/dl) on day 6 had a significantly longer PFS and OS compared to those above the median

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