Baby in Nepal Dies After Getting Six Vaccines

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Baby in Nepal Dies After Getting Six Vaccines

Baby in Nepal Dies After Getting Six Vaccines

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A six-week-old baby in Nepal died after receiving six vaccines. The child, Bunu Dewan, reportedly received the BCG, DPT, fIPV and PCV vaccines at a community health center in the town of Simaltar. Bunu’s condition is reported to have deteriorated following the vaccination and the child
was subsequently taken to Neuro Hospital in Biratnagar.1 2
The BCG (Bacillus Calmette–Guérin) vaccine is given to newborns at birth to protect them from contracting tuberculosis (TB). The DPT vaccine for diphtheria, pertussis and tetanus is scheduled to be given at six weeks, although it is now supposed to be given as part of a pentavalent vaccine that includes a dose of hepatitis B vaccine and Haemophilus influenza B vaccine.3 4
The fIPV, which stands for fractional inactivated polio vaccine, is also scheduled at six weeks, as are the PCV (pneumococcal conjugatve vaccine), OPV (oral polio vaccine) and rotarivus vaccine.4

Countries Are Switching from OPV to IPV

After wild poliovirus type 2 was declared eradicated in September 2015, countries like Nepal and India still using live oral polio vaccine (OPV) that contains type 1,2 and 3 polioviruses began switching from trivalent OPV to a bivalent OPV only containing types 1 and 3 as part of a global initiative to prevent type 2 vaccine strain poliovirus from circulating and causing vaccine strain polio. At the same time, there was a move toward encouraging use of injectable inactivated polio vaccine (IPV) that cannot cause vaccine strain polio (the U.S. switched from OPV to IPV in 1999).
Due to limited supplies of IPV worldwide, a fractionated version of IPV was developed that is given intradermally instead of intramuscularly and uses one-fifth the amount of antigen in a regular dose.5 According to the World Health Organization (WHO), the fIPV can be used as an “alternative to the intramuscular injection of a full dose of IPV” and that, in the context of an IPV shortage, countries should consider instituting a 2-dose fractional dose schedule, where feasible.”6

DPT Still Being Given to Infants in Many Countries

On Feb. 3, 2019, six-month-old Binod Ale Magar died in Kailali district of Nepal within hours of getting the DPT vaccine. Two other children, three-year-old Mihika Chaudhary and two-month-old Dipika Chaudhary, also received the DPT vaccine that day and became ill and developed rashes throughout their bodies.7
In 1996, the U.S. licensed an acellular pertussis vaccine (DTaP) for infants after global clinical trials demonstrated that DTaP causes far fewer serious reactions than DPT.8 9 10 According to the National Vaccine Information Center (NVIC), reactions to pertussis containing vaccines, both DPT and DTaP, usually occur within 72 hours or a week of vaccination and can include high fever, severe swelling and pain at the injection site, convulsions, high pitched screaming, collapse/shock (hypotonic/hyporesponsive episodes), encephalitis and encephalopathy.11

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