There are several longer duration fasting regimens that are available. I arbitrarily divide it at 24 hours but there is no physiologic reason to do so, other than for classification purposes. There is no magic dividing line. We covered fasting regimens using periods less than 24 hours in our last post. This post will cover those schedules that use fasts longer than 24 hours.

24 hour fasts
This period of fasting is essentially going from dinner to dinner, or breakfast to breakfast, whatever you like. For example, you would eat dinner at 7 pm and then fast until the next day’s dinner at 7 pm. In this regimen, you do not actually go a full day without eating since you are still taking one meal on that ‘fasting’ day.
This is very similar to the ‘Warrior’ style of fasting although that allows a 4 hour eating window so is technically a 20 hour fasting period.
This period of fasting has several important advantages. First, as a longer duration fast, it tends to be a little more effective. Because you still eat every day, medications that need to be taken with food can still be taken. For example, metformin, or iron supplements of aspirin should all be taken with food and can be taken with the one meal on the fasting day.
The other major advantage is that this style is the most easily incorporated into everyday life. Most people, for example will eat dinner with family every single day. As you still eat dinner every day, it is possible to routinely fast for 24 hours without anybody knowing any different, since it really only means skipping breakfast and lunch on that day.
This is particularly easy during a workday. You simply drink your morning cup of joe, but skip breakfast. You work through lunch and get home in time for dinner, again. This saves both time and money. There is no cleanup or cooking for breakfast. You save an hour at lunchtime where you can work, and be home for dinner without anybody even realizing you had fasted for 24 hrs.
Eat Stop Eat
This schedule of 24 hour fasting done once or twice per week is recommended by Brad Pilon in his book Eat, Stop, Eat (http://www.eatstopeat.org).  Brad was a bodybuilder who was a pioneer in popularizing intermittent fasting and really undertook a thorough review of the science behind fasting.
The 5:2 Diet

A related approach is the 5:2 approach championed by Dr. Michael Mosley, a TV producer and physician best known for popularizing this approach. He appeared on a BBC program called Horizon entitled “Eat, Fast, and Live Longer”.
While there had been some fringe interest being generated by pioneers such as Martin Berkhan and Brad Pilon, they had not really hit the mainstream yet. With the BBC documentary and the book that soon followed, intense interest, especially in the UK followed.
The book, entitled “The Fast Diet” became a best seller in the UK and soon other follow up books were released. The basic diet was not quite a 24 hour fasting period, as Brad Pilon described.
Instead, the 5:2 diet consisted of 5 days of normal diet. On the other two days, you could eat a total of 500 calories. Those 500 calories could be taken all in a single meal. If, for example, this is taken as dinner, it would be identical to the Eat, Stop, Eat diet. However, you could spread those 500 calories out into multiple meals instead. These two approaches are quite similar and the difference physiologically, is likely quite minimal.
Alternate Daily Fasting (ADF)
This is the dietary strategy that has the most research behind it. Much of it was done by Dr. Krista Varady, an assistant professor of nutrition with the University of Illinois – Chicago. She wrote a book about her strategy in The Every Other Day Diet, although this was not the blockbuster success of the 5:2 diet.
Krista Varady
Even though it sounds like you only eat every other day, it is not quite. You can eat up to 500 calories on fasting days, just like in the 5:2 diet. However, fasting days are done on alternate days rather than 2x per week so it is a more intensive regimen. The major advantage of this regimen is that more research is available on this regimen than any other. We will consider these studies in more detail in later posts.
36 hour fasts
As you progressively go longer in fasting, there benefits accrue faster, but there is also more risk of complications. Since I often deal with type 2 diabetics and hard to treat obesity cases, I tend to gravitate towards longer fasting periods, but you must understand that I always monitor very closely their blood pressures, and blood work and progress. I cannot stress enough, that if you do not feel well at any point, you must stop. You can be hungry, but you should not feel sick.
Another major consideration is that medication must be carefully monitored by a physician. The major problem are diabetic medications because if you take the same dose of medication and do not eat, you will become hypoglycaemic and that is very dangerous.
Blood sugars going low is not a complication per se, because that is generally the point of fasting. We want the sugars to go low. However, it does mean that you are overmedicated for that day. You must work very carefully with a physician to adjust medications and monitor sugars. Also, there are certain medications that may cause stomach upset on an empty stomach. NSAIDS, ASA, Iron supplements and metformin are the major drugs here.
In general, diabetic medicates and insulin MUST be reduced on the fasting day to avoid hypoglycaemia. Exactly how much to reduce it should be overseen by your physician.
I DO NOT RECOMMEND ANYBODY WHO IS TAKING ANY MEDICATION TO TRY LONGER FASTS WITHOUT CLEARING IT WITH THEIR DOCTOR. 
A 36 hour fast means that you fast one entire day. You finish dinner on day 1 at 7pm for instance, and you would skip all meals on day 2, and not eat again until breakfast at 7 am on day 3. So that is a total of 36 hours of fasting.
42 hour fasts
We often advise our clients to make a routine out of skipping the morning meal and break their fast around noon hour. This makes it easy to follow a 16:8 fasting period on regular days. After a few days, most people start to feel quite normal just starting their day with a glass of water and their usual cup of coffee.
When you combine that with a 36 hour fast, you get a 42 hour fasting period. For example, you would eat dinner at 6 pm on day 1. You skip all meals on day 2 and eat your regular ‘break fast’ meal at 12:00. This is a total of 42 hours.
For longer duration fasts, we often try NOT to calorie restrict during that eating period. Often, as people get used to fasting, we hear very often that their appetite starts to seriously go down. Not up. Down. They should eat to satiation on their eating day.
There’s a very good reason for this decrease in appetite. As you start to break the insulin resistance cycle, insulin levels start to decrease. Since insulin is the major regulator of the body set weight (BSW) your body now ‘wants’ to go lower. In response, hunger is suppressed and total energy expenditure is maintained. So – appetite goes down and TEE stays same or goes up. Remember that standard Caloric Reduction as Primary (CRaP) strategies produce the opposite. Appetite goes up and TEE goes down. Which do you think will work in the long run?
Start with Fasting part 1
Continue to Fasting part 8