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Title : Irina's mom genomic sequencing report
link : Irina's mom genomic sequencing report

Irina's mom genomic sequencing report

Dear Stephen! Dear all!

1) Could you please help me with genomic sequencing report!
Probably you could advice any beneficial drugs for our sitation.
Now we use DCA, metformine, chloroquine, celebrex, prozak, boswellia, pterostilbene, EGCG, BroccoMax, berberine, omega 3, milk thistle, cannabioids with high thc - 74%).












Options 1 and 3 have the most pathological nature.

• Option number 1 is located in the KDR gene, which is an oncogene, and involved in tumor angiogenesis processes.
• Option number 3 is in the gene PMS2, which belongs to the tumor suppressor genomes, and is involved in the repair of unpaired
• bases (edits DNA replication errors). Associated with many tumor diseases. This option, as follows from sources (column PMID) often has a germinal nature (is congenital).
• Option number 4 is located in the gene ROS1, which is a proto-oncogene, and encodes a number of tyrosine kinase receptors. He might be both congenital and acquired. 

These mutations currently have no targeted drugs.

Mutation load (Tmb) - high: 3.79 m/Mb (with a threshold value of 0.8 m/Mb)

Microsatellite instability (MSI) - presence (bottom line):

- 11.9% / 12% repeat

- mutations 2 reparation genes of 4

2) How do you think is it worth to try ONK201 drug for my mom if she don't have h3k27m mutation? I read on the forum on face book that many adults with glioblastoma without mutation use it and have positive results. 

Does it really kill tumor stem cells?

Thank you so much!

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