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Title : Temozolomide + mifepristone in rat glioma model
link : Temozolomide + mifepristone in rat glioma model

Temozolomide + mifepristone in rat glioma model

• Mifepristone, an FDA and Health Canada approved antiprogestogen, used to induce abortion.

• C6 rat glioma cells implanted into brains of male Wistar rats
• temozolomide applied to the rats at a dose of 5 mg/kg/day intraperitoneally
• mifepristone applied to the rats at a dose of 10 mg/kd/day subcutaneous injection
• rat survival as show below ("sham" refers to rats undergoing sham surgery with no glioma cells implanted)
• combination of temozolomide + mifepristone was effective where either single agent alone was  ineffective

Full study links here: https://www.mdpi.com/2072-6694/11/1/16

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