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Title : advices on cocktails and corticoids
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advices on cocktails and corticoids

My father in France - 71 years old - has been diagnosed with a GBM grade IV in September 2018. Before that he has always been in good shape and was very sportive.
He has 3 tumors from 10mm to 40mm and seems to be inoperable. He already had 3 sets of TMZ and he is taking already some supplements I recommended based on my researches on Internet. 
Here is his complete current treatment started 1 month after first diagnosis (time to perform biopsy) :

Temodal	3 cycles of 5 days done
Corticoids - Solupred	50 to 60 mg / day
Cannabis suppositories	1g / day (80% THC)
Chinese herbs and mushrooms (including Artemisia Annua)	every day
Vitamin C	5g / day
Nutraexpert Lipo HCA dietary suplements containing:
HCA	1500 mg / day
Alpha Lipoic Acid	1600 mg / day
Capsicum	112 mg/ day
Quercetin	45 mg/ day
Ginger	46 mg/ day
Whey	47 mg/ day
Green tea	30 mg/ day
Nicotinamid	20 mg/ day
Vitamin D3	25 µg/ 1000 UI
Ketogenic diet
Curcuma (Longvida) : added last week	1g / day

Biopsy revealed :

• IDH1 : negative
• FGFR3 : negative
• P53 protein : 15 - 20%
• no information on MGMT

MRI performed early december has show a slight size increase in the 2 biggest tumors, the oncologist says it is not alarming as the treament started one month after first diagnosis.
Currently my father resists well and tries to keep daily walking activity. Next MRI will be next month. 

I just recently discovered the cocktail approach and your blog and I have some questions.

1. It seems many patients are taking Melatonin 20 mg/ day (forbidden in France at this dosage by the way) and that it could be of good help : sustains the immune system, anti-oxidant, anti inflammatory, leads to cancer cells suicide ... Should I add Melatonin to the treatment ? It seems also that Malatonin is non compliant with corticoids as it inhibits corticoids effects : what do you think ?

2. More globally I fear corticoids may have a negative impact on the different supplements. Is there a mean to sustitute it by anything else ? Is Celebrex an option ? If so at which dosage ? (the inflammation is still important, but decreasing).

3. Would you have any recommandation in other supplements or drugs ? PSK mushroom, Valpoic Acid, Metformin? 

Thank you very much for your precious help.

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