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Title : Alpha lipoic acid and hypoxia
link : Alpha lipoic acid and hypoxia

Alpha lipoic acid and hypoxia

Some patients use alpha lipoic acid in the treatment of glioblastoma. For example, it is part of the Metablock protocol or is accepted to minimize side effects of DCA.

However, this new study contains strange conclusions:

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.

https://www.ncbi.nlm.nih.gov/pubmed/30590317
https://www.sciencedirect.com/science/article/pii/S0753332218355070?via%3Dihub

"More importantly, we found ALA reduced the percentage of apoptotic cells and increased the MTT levels in the cells.
...inhibition of TRPA1-mediated Ca2+ entry through ALA treatment may not be a potential strategy for killing the glioblastoma cancer cells"

As you know, the tumor is very often hypoxic due to the use of Avastin.

Does this mean that alpha-lipoic acid should be avoided if there is a suspicion that the tumor has become hypoxic?

Thus Article Alpha lipoic acid and hypoxia

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