Questions on Chloroquine for my mom

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Title : Questions on Chloroquine for my mom
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Questions on Chloroquine for my mom

Hi folks/Stephen,

My mom is a GBM patient who is EGFRvIII amplified, and basis my research and Stephen's inputs, I realised that Chloroquine is a great adjuvant for my mom. I have been reading up on Chloroquine and had the following questions on the same:

1. I am not able to find Chloroquine in my country, but Chloroquine phosphate instead. Can they both be used interchangeably? Is the efficacy of both just as good?

Basis my research, the dosage of Chloroquine should be 150 mg. What should be the dosage of Chloroquine Phosphate, if it can be used interchangeably?

2. I also read that Chloroquine is a chemo sensitiser, but couldn't find any information on what the timing of this drug should be for maximum efficacy.

My mom takes lomustine+temozolomide in the morning. Can you please help me on when the Chloroquine/Chloroquine Phosphate should be timed for maximum efficacy?

3. How long should chloroquine be taken for? Should it just be done till the chemotherapy or should it be done post the chemotherapy too? I see different researches doing this protocol differently.

My mom has completed 3 cycles of temozolomide and 4 cycles of temozolomide+lomustine. We plan to do two more cycles of temozolomide+lomustine and stop the chemo post that.

4. My mom is also doing the supplements in the table below.

a. My major concern is Artemisia since it is an anti malarial drug too. Is it safe to do both? If yes, how I should I time them so that I get the efficacy of both for my mom?

b. Is there any drug reaction that I should be concerned of? I researched on drugs.com for the interaction list, but all that I could find were two reactions since most of the naturopathic supplements were not there in their database(Interaction list for my mom is here). The two reactions that they talk of is reaction between Chloroquine and Keppra, Chloroquine and Celebrex, how big a concern are they?

Supplement Cap count
Boswellia Serratta 500 mg 8
Keppra 500 mg 2
Curcumin + Piperine 1 g 4
Longvida 400 mg 2
Metformin 500 mg 3
Quercetin 865 mg 4
Resveratrol 200 mg 2
Bromelain 500 mg 6
TMG 1 g 3
Reishi 1g 2
Mebendezole 100 mg for 3 months + Doxycycline 100 mg for 1 month
(We have skipped the statins from the care oncology protocol fearing it might be too heavy on her liver)
1
Artimisia 1 g 2
Ashwagandha 500 mg 1
Selinium 200 mcg 1
Vitamin A + D + K2 - 5000 IU 1
Molybdenum Glycenate 1g 1
Celebrex 200 mg 2
Green tea extract 500 mg 40% EGCG 2
Marrow Plus 6
Echinisea 500 mg 3
Astragalus tea 3g 1
Juice from 5g of Ginger 1
Garlic 2 cloves 3



I look forward to your response!


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