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Title : CDK4/6 inhibitors
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CDK4/6 inhibitors

My father was diagnosed with GBM a few months ago and a recent molecular screening suggests that CDK4/6 inhibitors may be of use as a form of therapy due to evidence of 'CDK4 amplification'.  

Following my own research, there seem to be three CDK4/6 inhibitor drugs available:

1) ribociclib (Kisqali) 

2) palbociclib (lbrance) 

3) abemaciclib

Does anyone have any experience with the above drugs in terms of toxicity, side effects, dose etc?

Are there any drugs that are known to, or have some evidence to suggest that they may work synergistically (or to have negative interactions) with these three? 

Apart from the three drugs above, does anyone know of any other CDK4/6 inhibitors?

Any inputs would be much appreciated! Thanks!

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