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Title : Metronomic, Optune & cocktail?
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Metronomic, Optune & cocktail?

A friend (48 yr old male, full resection 2 mos ago) has recently completed 6 weeks of RT and TMZ. He has discussed the possibility of metronomic vs. 5-day dose-intense schedule due to unmethylated MGMT status and EGFR overexpression mutation. He has a medical oncologist and a neuro oncologist. The medical oncologist didn't see one way or another would be preferable. The NO is still considering. Per Ben Williams, we know it is "worthy of consideration" to try the medium-dose metronomic schedule for unmethylated, amplified EGFR. I have read the study that seems compelling, but it is not conclusive based on being retrospective and having potential selection bias. Is there any other data or personal experiences on whether if given the choice, one would choose a metronomic schedule early on instead of doing this only at a recurrence for unmethylated EGFR amplied patient? 

Thank you for this great resource. I will include his cocktail in case you have other recommendations or questions. 

Keppra 500/2X

Pepcid 20 mg/2X

Celebrex 200 mg/2X

Atorvastatin 40 mg/2X (will increase to 80)

Mebendazone 100 mg

Valcyte 900 mg/2X

Bosweillic acid 3,000 mg

SBI protect (for GI protection)

Omega fish oil 1250 mg/2X

Coriolis/PSK 4.4 mg

Vit D 5,000 IU

Curcumin 1,000 mg (Seems to cause diarrhea, trying to increase)

Probiotic

Selenium 200 mcg

Magnesium 120 mg

Green tea extract 1,000 mg/2X

Melatonin 20 mg

Ginseng 500 mg

Astragalus 1,500/2X 

Milk thistle

Strict Ketogenic diet

Doctor advised against DCA (says not enough data to support), chloroquine (risk of retinopathy) or CBD oil (short-term memory problems), LDN (doesn't think it is effective)--if anyone wants to comment on these.b

Finally, he is on the fence about Optune if you have any experience with the lifestyle aspect of using it.  Our gratitude and best wishes to all of you.

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