Cocktail approach during radiation

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Cocktail approach during radiation

I am about to start radiation and temozolomide for the next 6 weeks and I'm not sure which specific drugs can be combined with TMZ during this stage. Can someone point me to a reference or if you have the knowledge on hand? I couldn't immediately find such a reference specifically for the radiation phase. 

My neurooncologist told me that I should be very careful about taking additional drugs during this radiation as different combinations don't have proven efficacy (TMZ may decrease in efficacy) and the toxicity of combinations can also be unknown. So I've looked into this, but I would appreciate any feedback. 

I understand that a different blog post (Rich cocktail), which might be a bit dated (3 years ago), is focused on treatment in general and not specifically for the phase of during radiation. 

Here is the list that I would like to try out during radiation. Is there anything you would add/modify? 
  • Valproic acid (because I'm currently on Keppra, I may have to switch off of Keppra to take Valproic acid since I may not need multiple anti-seizure medications?)
  • Metformin
  • CBD Oil
  • Iron supplement
  • PSK 
  • Alkylglycerols (possible liver side effects)
  • Green tea
  • selenium
  • magnesium
  • Boswellia serrata 
  • Chloroquine phosphate
I'm MGMT unmethylated so I believe the TMZ efficacy doesn't seem as concerning. 


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