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Title : Baseline corticosteroids reduce activity of PD-L1 blockade
link : Baseline corticosteroids reduce activity of PD-L1 blockade

Baseline corticosteroids reduce activity of PD-L1 blockade

https://www.ncbi.nlm.nih.gov/pubmed/30125216 
Impact of Baseline Steroids on Efficacy of Programmed Cell Death-1 and Programmed Death-Ligand 1 Blockade in Patients With Non-Small-Cell Lung Cancer

http://sci-hub.tw/https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30666-1/fulltext  (summary of study published in the Lancet)

"Baseline corticosteroid use was associated with decreased overall response, and shorter median progression-free survival and overall survival in patients who received the equivalent to 10 mg prednisone or more per day at the start of the PD-L1 blockade."

10 mg of prednisone is equivalent to only 1.6 mg of dexamethasone.

http://clincalc.com/corticosteroids/

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