5-azacytidine + temozolomide improves survival in IDH1 mutant mouse model - Hallo friendsTOP POLENNEWS, In the article you read this time with the title 5-azacytidine + temozolomide improves survival in IDH1 mutant mouse model, We have prepared this article for you to read and retrieve information therein. Hopefully the contents of postings Article cultur, Article economic, Article health, Article news, Article politique, Article sport, We write this you can understand. Alright, good read.

Title : 5-azacytidine + temozolomide improves survival in IDH1 mutant mouse model
link : 5-azacytidine + temozolomide improves survival in IDH1 mutant mouse model

5-azacytidine + temozolomide improves survival in IDH1 mutant mouse model

Demethylation and epigenetic modification with 5-Azacytidine reduces IDH1 mutant glioma growth in combination with Temozolomide.

https://www.ncbi.nlm.nih.gov/pubmed/30184215  (pubmed abstract)

click here for full study via sci-hub

In a mouse model of IDH1-mutant brain tumors, 5-azacytidine alone improved mouse survival, and the addition of 5-azacytidine to temozolomide significantly improved survival compared to temozolomide alone.

5-azacytidine is a hypomethylating (or demethylating) agent approved and commonly used to treat acute myeloid leukemia and myelodysplastic syndrome.

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