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Title : What to add to Irinotecan + Avastin
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What to add to Irinotecan + Avastin

Hi everyone,

I have a few questions I was hoping I could get some opinions on. My husband is receiving treatment for his second GBM recurrence-- currently on irinotecan and Avastin. I'm feeling unsure of what I can combine with this and I have a few specific questions:

- Is it safe to add Accutane? I have read on this blog that it could affect chemotherapy treatment but is that still the case with irinotecan since it uses a different mechanism?

- Would it be wise to consult with his doctor about adding the ALA-hydroxycitrate-naltrexone  treatment in addition to this?

- At what point do you change up additional treatments or supplements? He was using POH with a nebulizer but we stopped that after progression and I'm just not sure if we should continue it. Same with other supplements and prescriptions he has been taking. For instance, I'm not sure if he should continue taking metformin or if he should up the dose? (currently 500mg twice a day).

I'd be interested to hear anyone's experience with irinotecan/Avastin. So far, he's tolerated it well and it has improved a number of his symptoms but he has experienced some confusion and he will be getting an MRI soon. I'm desperately seeking clinical trials that he might qualify for but between the Avastin treatment, his speech issues and the fact that he'd technically be on his third recurrence by the time he's even eligible for a trial, our options for anything promising are incredibly limited. His doctors have told me that a vaccine type of therapy might be the most effective. I'm considering IOZK after reading some posts about it here and doing some research.

My husband is 32, we have two young kids and I fear that we are quickly running out of options. Thank you again to all who share here!

Abby

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