Title : First results of cocktail trial (memantine, metformin, mefloquine, temozolomide)
link : First results of cocktail trial (memantine, metformin, mefloquine, temozolomide)
First results of cocktail trial (memantine, metformin, mefloquine, temozolomide)
I'll be working on a review of the latest brain tumor news coming from the ASCO conference currently underway. Since this is the brain tumor cocktails blog, thought I'd post these results to start off.Phase I factorial study of temozolomide plus memantine, mefloquine, and metformin as post-radiation adjuvant therapy for newly diagnosed glioblastoma.
https://meetinglibrary.asco.org/record/164026/abstract
The abstract gives maximum tolerated doses for doublet therapy (TMZ + one of the other drugs), triplet, and quadruplet combinations.
2 year survival rate for the entire trial population (all combintions) was 43%, similar to the 2-year survival seen in the EF-14 trial for the Optune + TMZ arm.
Since some of the combinations were probably more effective than others, it will be interesting to see the results when separated by treatment arm.
Thus Article First results of cocktail trial (memantine, metformin, mefloquine, temozolomide)
That's an article First results of cocktail trial (memantine, metformin, mefloquine, temozolomide) This time, hopefully can give benefits to all of you. well, see you in posting other articles.
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