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Title : Androgen receptor as a potential druggable target in GBM
link : Androgen receptor as a potential druggable target in GBM

Androgen receptor as a potential druggable target in GBM

I took note of this abstract from the SNO 2017 abstracts:

CSIG-24. ANDROGEN RECEPTOR IS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA  (click on the title for the abstract)

The full study was just published in Oncotarget.  

https://www.ncbi.nlm.nih.gov/pubmed/29731997

"The AR gene was amplified in 27% of glioblastoma specimens from men (n=22) and of 38.2% from women (n=21). AR-RNA was overexpressed (>2.5 fold) in 93% (n=30), and AR-protein was induced (>two fold) in 56% of the glioblastomas samples (n=16). Thirty percent of the glioblastomas (n=21) also expressed a constitutively active AR-splice-variant (AR-V7/AR3) lacking the Ligand-Binding-Domain."

"Enzalutamide given orally to nude mice bearing subcutaneous human glioma xenografts resulted in a 72% reduction in tumor volume (p=0.0027)."

Thus Article Androgen receptor as a potential druggable target in GBM

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