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Title : Semyon's mom's profile.
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Semyon's mom's profile.

My mother had an operation (in Germany, Frankfurt am Main) - removal of the tumor by 99%, and then - the rapid growth of the tumor to its former size (for 3 weeks)! The doctors were in shock.
10 days after chemoradiotherapy, MRI still showed tumor growth. The doctors decided that TMZ did not work in our case and suggested urgently switching to Avastin and Irinotecan.

Thinking, we decided to use a low dose of Avastin + CCNU.
I also decided to add 5 days of low TMZ after every day of CCNU. One month after the second course of CCNU + TMZ, platelets fell to 70,000, and white blood cells to 2.47.
I waited 54 days for the mother's blood to recover. Now platelets: 140,000, leukocytes: 2.46. (Leukocytes are low probably because of the daily Sirolimus).

The OncoDeep report showed the likely effect of Sirolimus, Olaparib and Trametinib.
I flew to Delhi (India) and bought at low price LYNPARZA Olaparib (1 bottle of 112 capsules of 50 mg) and MEKINIST Trametinib (1 bottle of 30 2 mg tablets).

I can not wait any longer and must decide what the third cycle should be.
Here are my options:
1. CCNU 90mg / m2 + 5 days TMZ 90mg / m2
There is a risk of severe damage to the blood and a prolonged break until the next cycle.

2. CCNU 50mg / m2 + 5 days TMZ 90mg / m2
There is no such damage to the blood, but will there be an effect?

3. 5 days TMZ 150mg / m2
Not as effective as CCNU + TMZ. In addition, TMZ alone did not work in chemoradiotherapy. Will it work now? Stephen wrote an interesting opinion that if we alternate the cycles of TMZ and CCNU, then the tumors will be more difficult to adjust.

Also I think, how and when to use:
Olaparib 150mg / day 3 days in each week?
Trametinib 2mg / day?
I also think about metronomic temozolomide ...

Unfortunately, I am compelled to make this decision and I have to consult with whom, except with you in this blog, because in Russia one doctor advised the protocol Stupp, the other - Avastin + Irinotecan. And all the doctors categorically oppose any supplements and diets!

Unfortunately, it is very difficult to interpret MRI. 3 doctors who watch my mom's MRI say sometimes the opposite conclusion!

I will be very happy with any of your opinions.

Comments:

1. Suppression of T4 is very slow. We spent 3.5 months to reduce T4 from 12.4 to 3.3pmol / l. Also, T3 has fallen dramatically, although we take synthetic T3. Because of this, drowsiness and lack of appetite.

2. For all treatment, my mother lost a lot of weight. From 65 kg (in January) to 52 kg (now). However, I do not see anything that we could refuse.

3. We bought a special meter and ketone strips to check that the mother is ketosis.

4. I ordered Mebendazole chewable tablets from Thailand for 500 mg / tablet. Maybe we will try to take large doses: 2-3 grams per day.

5. We use a higher dose of perillyl alcohol than Dr. Dr. Clóvis Orlando: 30 drops instead of 21. No unpleasant sensations! We plan to increase the dose to 40 drops. Dr. Clóvis Orlando wrote that they use perillic alcohol of 96% from Sigma Aldrich and that the other perillyl alcohol will not have an effect on GBM.

MRI-1: https://drive.google.com/open?id=1tPKrQgjIZzBgefhkknxNlQKbaC04XMI_

MRI-2: https://drive.google.com/open?id=1t3SgxGgJFi19i9qIwc47JucsV6ZCbLFa

MRI-3: https://drive.google.com/open?id=1JbRYk3DCUK87ndeRQK-Q7V7130oObiMV

MRI-4: https://drive.google.com/open?id=1Q6WFd9qtFAd18czkd5ouKYloIVBKuFS1

MRI-5: https://drive.google.com/open?id=1L-O1BgoVMohI7eXxH35qN__rNBDy3hrM

MRI-6: https://drive.google.com/open?id=1xWYd5_UsrAYb-c4wv49DSWTeJEN8Dl_F

MRI-7: https://drive.google.com/open?id=1MCpzZxPnl7eI1iigzJVWrOo2o4s8hKWz

MRI-8: https://drive.google.com/open?id=1De95kb-iZ30X7scIbZkeXxFq4KV5fgdT

OncoDEEP report: https://drive.google.com/open?id=1A3dophOME6gY1GNdOHWE48wVYJUu_nHc
http://btcocktails.blogspot.ru/2018/02/our-report-oncodeep-what-do-you.html

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