Title : Reaction between supplements and CCNU/TMZ combination?
link : Reaction between supplements and CCNU/TMZ combination?
Reaction between supplements and CCNU/TMZ combination?
Hi folks/Stephen,
My mother, a GBM patient(Methylated) has completed 3 Temozolomide cycles and starts with her next cycle being Temozolomide + Lomustine. She is on the following supplements:
Boswellia Seratta 4 g/day, Keppra 1000 mg/day, Curcumin 3 g/day, Quercetin(4 g/day), Fish Oil 4 g/day, Resveratrol (400 mg/day), Marrow Plus(6 caps/day), Echinsea(2 g/day), Bromelain, Ginger, Garlic, Ashwagandha, Melatonin, Vitamin D3, Selinium, Molydenum, Artemesia, Malatonin 1500 mg/day, Melatonin 20mg/day, EGCG extract 400 mg/day, Celebrex 600 mg/day
Plan to add: Care Oncology Protocol, Ruta 6 + Calceria Phos, Cannabis Oil, Low dose Naltrexone
I had three questions, would be great if you could answer:
1. My mom's blood counts are still not really good. Her WBC count is 1700 and her Platelet count is 120k. My oncologist is suggesting we start the chemotherapy protocol as it has already been 28 days since the last temozolomide cycle. He says that we will use fligrastim injections(WBC injections) to manage the further dip in WBC counts, if at all they happen. Wanted to know if any of you have an experience/knowledge of whether it is okay to start the temozolomide+Lomustine combination with the low counts that my mom has, or should I wait further? I ask because my oncologist is using this combination on a GBM patient for the first time, and he thinks it is a little late already to start.
I also ask this because typically the gap between two TMZ + Lomustine cycles is 36 days(6 days of chemo + 36 days for the next cycle, making it a 6 week cycle), while the gap between two Temzolomide cycles is 23 days. Wondering what should be the maximum allowable gap between a temozolomide cycle and a temozolomide+lomustine cycle to make sure the efficacy of the chemotherapy is maintained.
2. I also wanted to know if I should be cautious of any of the supplements? I've read the Ben Williams book in good detail, and all of them talk of how the above supplements increase the efficacy of temozolomide, I don't really know if there is any reaction between lomustine and the above mentioned supplements, and that I need to be careful with or should I consider dosing down on?
3. Are there any adjuvants that you would suggest that can further help increase the efficacy of this combination? I was considering methadone, which I've read works really well with temozolomide, but I'm not sure if it'll work with this combination.
PS: I'd like to mention that I complete 7 months in this extremely tough journey, and this blog is my go to place to find quality answers to my queries. Thank you Stephen for sharing your knowledge and to all the members of this blog for sharing your experiences with us :)
My mother, a GBM patient(Methylated) has completed 3 Temozolomide cycles and starts with her next cycle being Temozolomide + Lomustine. She is on the following supplements:
Boswellia Seratta 4 g/day, Keppra 1000 mg/day, Curcumin 3 g/day, Quercetin(4 g/day), Fish Oil 4 g/day, Resveratrol (400 mg/day), Marrow Plus(6 caps/day), Echinsea(2 g/day), Bromelain, Ginger, Garlic, Ashwagandha, Melatonin, Vitamin D3, Selinium, Molydenum, Artemesia, Malatonin 1500 mg/day, Melatonin 20mg/day, EGCG extract 400 mg/day, Celebrex 600 mg/day
Plan to add: Care Oncology Protocol, Ruta 6 + Calceria Phos, Cannabis Oil, Low dose Naltrexone
I had three questions, would be great if you could answer:
1. My mom's blood counts are still not really good. Her WBC count is 1700 and her Platelet count is 120k. My oncologist is suggesting we start the chemotherapy protocol as it has already been 28 days since the last temozolomide cycle. He says that we will use fligrastim injections(WBC injections) to manage the further dip in WBC counts, if at all they happen. Wanted to know if any of you have an experience/knowledge of whether it is okay to start the temozolomide+Lomustine combination with the low counts that my mom has, or should I wait further? I ask because my oncologist is using this combination on a GBM patient for the first time, and he thinks it is a little late already to start.
I also ask this because typically the gap between two TMZ + Lomustine cycles is 36 days(6 days of chemo + 36 days for the next cycle, making it a 6 week cycle), while the gap between two Temzolomide cycles is 23 days. Wondering what should be the maximum allowable gap between a temozolomide cycle and a temozolomide+lomustine cycle to make sure the efficacy of the chemotherapy is maintained.
2. I also wanted to know if I should be cautious of any of the supplements? I've read the Ben Williams book in good detail, and all of them talk of how the above supplements increase the efficacy of temozolomide, I don't really know if there is any reaction between lomustine and the above mentioned supplements, and that I need to be careful with or should I consider dosing down on?
3. Are there any adjuvants that you would suggest that can further help increase the efficacy of this combination? I was considering methadone, which I've read works really well with temozolomide, but I'm not sure if it'll work with this combination.
PS: I'd like to mention that I complete 7 months in this extremely tough journey, and this blog is my go to place to find quality answers to my queries. Thank you Stephen for sharing your knowledge and to all the members of this blog for sharing your experiences with us :)
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