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Title : leucine restriction for IDH1mut?
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leucine restriction for IDH1mut?

Hi all,

This article here says that leucine is an activator of GLUD2.

http://ift.tt/2nOBbcX

This is the article they sited:

http://ift.tt/2nWYssK

Leucine is an essential amino acid, which means we must eat it in order to get it. The first article seems to say that leucine is stored in IDH1 mutant gliomas…but I read another article that this depends on the concentrations of ADP and L-Leucine — which implies they can be diluted. Is there an ADP inhibitor? (An initial google search seems to say there is but I'm not sure how they will impact the brain or health in general. I'm going to search that when I have more time.)


Thanks.
Maria

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