Plerixafor - new drug to cocktail?

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Title : Plerixafor - new drug to cocktail?
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Plerixafor - new drug to cocktail?

Hello!
1. There is one promising report on the treatment of TMZ+Plerixafor (+Lapatinib  pulse dosing) for glioblastoma:
http://ift.tt/2AjxxMG/
Plerixafor was administered subcutaneously 1 time per week for 2 years.

2. And one ongoing trial studie at phase II:
http://ift.tt/2z8Pmjb

Plerixafor was administered via continuous intravenous infusion of 400 micrograms/kg/day starting one week prior to end of RT and continuing for 4 weeks.
Here are published abstratcs:
http://ift.tt/2AnaOz2
http://ift.tt/2z9c6iZ


Stephen wrote that 1 shot of Plerixafor is very expensive, but I am in Delhi (India) and here Plerixafor 24mg/1.2 ml (Celrixafor by Celon Labs) is $ 1000.

What do You think about this medication and what are the tactics of its use more effective?


What do You think about Lapatinib used in the first case, pulse dosing? If it is suitable for all types of glioblastoma? clinical research is also going on:
http://ift.tt/2z8PoHP


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