Title : Levi's cocktail update & pretty good MRI at 8 months
link : Levi's cocktail update & pretty good MRI at 8 months
Levi's cocktail update & pretty good MRI at 8 months
Luckily my husband (who is MGMT methylated, wild type and has a multifocal tumor) got a quite promising MRI report today after a slight progression in late August following radiation therapy. We need to wait for the NO's opinion till 12/18 but it's clear for us that this is good news because the report contains words like regression (both in the thalamic and frontobasal areas), reduced T2 signaling, reduced edema.
The only negative statement mentions increased rCBV at some parts of the frontobasal tumor. Good results were not so surprising since he is doing very well. He basically slept through the 2 months after radiation therapy but now he is is back to normal. His only deficiency is left-side peripheral vision loss due to surgery.
Since my previous post we made some changes to his cocktail. Thanks to a nice blog member's guidance my husband started to take D,L methadone a month ago. He will reach the therapeutic dose (2 x 35 drops) soon. It didn't have enough time to make a difference yet so I chalk the fairly good MRI results up to the cocktail approach. I hope that the next MRI in late February / early March will be even better thanks to methadone.
With mebendazole, we try to follow Care Oncology's protocol so after the 3 months course of mebendazole which he we'll complete within days we'll alternate it with minocycline (instead of doxycyclin). Somebody stated on a forum that mebendazole and minocycline do the same job. I suppose mebendazole isn't the strongest part of our cocktail considering its bioavailability and the fact that he takes way less than the dosage used in clinical trials. So maybe it would be wiser to choose minocycline on the long term. What do you think, dear fighters & relatives, should we pick the substitution alternative or should we favour minocycline? If so, which one would be better, 100 mg or 200 mg? I have concerns about putting all our eggs in one basket. Maybe if the current cocktail works we can keep up with it, otherwise what will we have left in case of a progression if we blow all our ammunition now?
Current cocktail:
Tried to increase it to 380 mg for one cycle but BP dropped to 40,000 so it turns out that he can tolerate only 280 mg.
Morning, on an empty stomach:
1,5 g PSK mushroom
250 mg EGCG (500 mg on TMZ days + fresh green tea)
1000 mcg sulforaphane from dried broccoli sprouts (2000 mcg on TMZ days)
2000 mg Fish Oil
250 mg vitamine C
D,L methadone 25 drops
0.5 liter of beetroot-carrot-apple-orange juice ( I don't really believe that it can help but at least it's delicious.) I used to make fresh pomegranate juice daily but then I read that it can increase the concentration of corticosteroids so we stopped it.
After breakfast:
Curcumin 1000 mg
Fluoxetine 40 mg
Alfacalcidol 2.5 mcg
Metformin 500 mg
After lunch:
mebendazole 100 mg / minocycline 100 mg
methylprednisolone 16 mg (I hope it'll be reduced after the next meeting with the NO)
cimetidine 2 x 200 mg
During the afternoon & evening
cimetidine 1 x 200 mg
silymarin 630 mg (I increase it on TMZ days to 850 mg but just like everybody else I'm just guessing with the dosage)
celebrex 400 mg
metformin 500 mg (1500 mg on TMZ days in total)
DCA 500 mg x 2 + 500 mg B1, 2 weeks on, 1 week off
This means 15.6 mg/ kg. He was on 500 mg x 3 / 20.4 mg/ kg for several weeks, parallel with his Temodal cycle increased to 380 mg but it caused neuropathy in his hands and feets and balance issues so we decreased DCA to 15.6 mg/ kg and symptoms disappeared. I'm not sure if it was Temodal or DCA because both of them were decreased after these issues. Now, we try DCA without B1. We'll see...
After dinner:
Chloroquine (Delagil) 250 mg (Only every other day since he takes cimetidine.)
Selenium 200 mcg
cup of tomato juice as Lycopene source
Before bedtime:
D,L methadone 25 drops
melatonin 20 mg
PSK 1.5 g
cimetidine 1 x 200 mg
- Omeprazole 40 mg x 2 (2 days before and 2 days after TMZ days)
Thus Article Levi's cocktail update & pretty good MRI at 8 months
That's an article Levi's cocktail update & pretty good MRI at 8 months This time, hopefully can give benefits to all of you. well, see you in posting other articles.
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